It’s a comfort food to the rescue day! I have an easy, cheesy, and low-carb healthy Spaghetti Squash Casserole recipe for you. Whether you are looking for a meal to match your cozy night on the couch…or are already anticipating the week of easy, healthy dinners you are going to need after the weekend, this casserole has you covered!

Spaghetti Squash Casserole with ground turkey, tomatoes, and Italian spices. Easy, CHEESY, and healthy! An all-in-one low carb meal. Recipe at wellplated.com | @wellplated

Growing up, spaghetti squash was an “on the side” affair…and even then, only if was topped with an appropriate level of butter and brown sugar. I still enjoy baked spaghetti squash this way every now and then for the sake of nostalgia—and because who am I pretending to be here? It’s delicious. I’ve also come to adore spaghetti squash as a component of more savory sides such as Roasted Spaghetti Squash with Parmesan Mushrooms and main dish recipes like Taco Spaghetti Squash Boats, Spaghetti Squash Boats with Chicken and Bacon, and today’s Italian-inspired Spaghetti Squash Casserole.

The casserole filling is an easy mix of roasted and shredded spaghetti squash, diced tomatoes, bell peppers, Italian spices, and ground turkey (you can do the Spaghetti Squash Casserole with chicken instead if you prefer). All of the ingredients cook together in a single pan, and you can even get a head start by roasting the spaghetti squash up to three days in advance.

Healthy Spaghetti Squash Casserole with turkey, tomatoes, and Italian spices. Low carb, easy, and so satisfying! Recipe at wellplated.com | @wellplated

The Making of Spaghetti Squash Casserole

If spaghetti squash has been mostly a side hustle on your dinner plate too, this Spaghetti Squash Casserole with ground turkey is the perfect way to explore its versatility in main-dish recipes. The squash’s neutral flavor makes it easy to blend with a wide range of flavors, it adds bulk to just about any recipe, and it’s packed with vitamins C and A and high in fiber.

It also keeps this Spaghetti Squash Casserole low carb. One serving of this healthy casserole has just 8 grams of carbs and a whopping 20 grams of protein!

Healthy Spaghetti Squash Casserole. Easy, cheesy, and DELICIOUS. A low carb dinner your whole family will love! Recipe at wellplated.com | @wellplated

A shower of low-fat mozzarella on top gives this casserole that iconic bubbly, cheesy casserole “lid,” but if you are avoiding dairy or want to make this Spaghetti Squash Casserole Paleo, you can always omit it. Household members divided on the cheese? Keep it on the side and allow each person to sprinkle on his or her own.

Make Ahead and Storage Tips

  • To Make Ahead. Spaghetti squash can be roasted, shredded, and stored in an airtight container for up to 3 days. When ready to make the casserole, add to the filling in Step 2 as directed.
  • To Store. Store leftovers in the refrigerator for up to 5 days.
  • To Freeze. I haven’t tried freezing the casserole yet, but as a reader pointed out in the comments (thanks, Andrea!), spaghetti squash can get watery when thawed. If that doesn’t bother you, here’s what to do: Bake as directed, let cool, and then tightly cover and freeze for up to 3 months. Let thaw in the refrigerator overnight. Heat in a 350 degree F oven, covered, until warmed through. Uncover and bake 5 or so additional minutes, until hot and bubbly.
Spaghetti Squash Casserole. Easy, cheesy, and healthy! A low-carb meal with turkey, tomatoes, and Italian spices. Recipe at wellplated.com | @wellplated

More Delicious Spaghetti Squash Recipes

For a little step by step, I have a new video for you below. If you try this recipe, I’d love to know what you think. Thanks as always for your kind reviews and the 5-star ratings too. I can’t say enough how much they mean to me and how helpful they are to others who might be considering the recipe too!

Spaghetti Squash Casserole with ground turkey, tomatoes, and Italian spices. Easy, CHEESY, and healthy! An all-in-one low carb meal. Recipe at wellplated.com | @wellplated

Spaghetti Squash Casserole

4.95 from 67 votes
Healthy Spaghetti Squash Casserole with ground turkey, tomatoes, and Italian spices. Easy, CHEESY, and a crowdpleaser. Low-carb and gluten-free recipe!

Prep: 10 mins
Cook: 1 hr 15 mins
Total: 1 hr 25 mins

Servings: 6 servings

Ingredients
  

  • 1 small/medium spaghetti squash about 2 pounds
  • 2 teaspoons extra-virgin olive oil
  • 1 pound 93% lean ground turkey
  • 1 small red onion diced
  • 1 green bell pepper cored and diced
  • 1 teaspoon kosher salt
  • ½ teaspoon black pepper
  • 1 can 14.5-ounce diced tomatoes with Italian spices, drained
  • 3 cloves garlic minced
  • 1 teaspoon Italian seasonings of choice or a mix of oregano, basil, and thyme
  • ½ teaspoon crushed red pepper flakes reduce to ¼ teaspoon if sensitive to spice
  • 1 cup freshly grated part-skim mozzarella or provolone cheese divided
  • Chopped fresh parsley or basil

Instructions
 

  • Place a rack in the center of your oven and preheat the oven to 400 degrees F. Roast the spaghetti squash according to this recipe for Roasted Spaghetti Squash. When cool enough to handle, pull the squash strings out of the squash's center with a fork and transfer to a large mixing bowl. The squash strings should look like spaghetti.
  • Reduce the oven temperature to 350 degrees F. Heat the olive oil in a large, deep skillet over medium high. Add the turkey, onion, bell pepper, salt, and black pepper. Cook, breaking apart the meat, until meat is browned and the vegetables are tender, about 8 minutes. Add the drained tomatoes, garlic, Italian seasoning, and red pepper flakes. Let cook until most of the liquid from the tomatoes has cooked off, about 4 minutes, and then add the reserved squash. Cook and stir until most of the remaining liquid has cooked off, about 1 to 2 minutes more, increasing the heat if needed. Stir in ½ cup of the shredded cheese. There may be some liquid remaining in the pan.
  • Lightly coat a deep 8×8-inch baking dish or 2-quart casserole dish with nonstick spray. With a slotted spoon, scoop the squash mixture into the pan in an even layer, discarding any excess liquid (some in the pan is OK—just not too much). Bake, uncovered, for 20 minutes. Remove from the oven and sprinkle with the remaining ½ cup cheese, and then return to the oven and bake until the cheese melts, about 5 to 10 additional minutes. For an extra-golden-brown top, place the casserole under the broiler for a few minutes. Remove from the oven, sprinkle with parsley and/or basil, and let rest 5 minutes. Serve hot.

Notes

  • Make it ahead: Spaghetti squash can be roasted, shredded, and stored in an airtight container for up to 3 days. When ready to make the casserole, add to the filling in Step 2 as directed.
  • Store leftovers in the refrigerator for up to 5 days.
  • I haven’t tried freezing the casserole yet, but as a reader pointed out in the comments (thanks, Andrea!), spaghetti squash can get watery when thawed. If that doesn’t bother you, here’s what to do: Bake as directed, let cool, and then tightly cover and freeze for up to 3 months. Let thaw in the refrigerator overnight. Heat in a 350 degree F oven, covered, until warmed through. Uncover and bake 5 or so additional minutes, until hot and bubbly.
  • To make Paleo or Whole30 friendly: omit the cheese

Nutrition

Serving: 1(of 6)Calories: 193kcalCarbohydrates: 8gProtein: 20gFat: 10gSaturated Fat: 4gCholesterol: 71mgSodium: 478mgFiber: 2gSugar: 3g

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Erin Clarke

Hi, I'm Erin Clarke, and I'm fearlessly dedicated to making healthy food that's affordable, easy-to-make, and best of all DELISH. I'm the author and recipe developer here at wellplated.com and of The Well Plated Cookbook. I adore both sweets and veggies, and I am on a mission to save you time and dishes. WELCOME!

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206 Comments

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  1. This was soooo good! I’m a very picky eater and there were definitely things in this that I would usually pick out, but instead found myself cleaning the plate of everything! From other recipes I have made, I decided to use fire roasted tomatoes instead of regular and because it makes everything better, added some fresh grated Parmesan cheese. Making this again and again! 5 stars

  2. I just made your crockpot Mexican chicken for tonight and it is delicious! Pinning this recipe of yours with the spaghetti squash to my casseroles board for future reference.5 stars

  3. Made this but it was lacking in some depth of flavor, so I added a cup of marinara sauce to it. Could have added a little more even – but it made the difference. Never really had had spaghetti squash, so I was surprised that I like it!!4 stars

  4. Let’s fast forward to 2020 and the year of C. Made this and it was amazing. Comfort food is so helpful at this time. Please take care of yourself and your family. I will be visiting your site for more delicious recipes. Stay healthy.5 stars

  5. This was so tasty! Will be making it all fall & winter. Love the idea of adding diced butternut to it too, in that early step where you’re sautéing the veggies with the turkey. 5 stars

  6. This recipe is the best way to enjoy spaghetti squash! It’s simple but so tasty (don’t skimp on garlic and seasonings!) and comes together easily. I think it’s a good recipe for those hesitant to try squash. *Full disclosure, I did use ground chicken instead of turkey.5 stars

  7. Very Good! Added mushrooms with sautee step. Also used fire roasted tomatoes. Don’t skip on salt when using turkey and take the time to reduce the juices before adding the squash and cheese.5 stars

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